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Crohn's Disease: Case Western Reserve Researchers Identify Links Between Inflammatory Disease Genes
Researchers from Case Western Reserve University School of Medicine identified a novel link between ITCH, a gene known to regulate inflammation in the body and NOD2, a gene which causes the majority of genetic Crohn"s Disease diagnoses. ITCH, when malfunctioning, causes widespread inflammatory diseases, including inflammatory bowel disease, gastritis, uncontrolled skin inflammation, and pulmonary pneumonitis. Derek Abbott, M.D., Ph.D., and his team of researchers found that ITCH also influences NOD2-induced inflammation. These findings, published in the August 11th issue of Current Biology, suggest a common pathophysiology exists between multiple inflammatory diseases. The unexpected finding of the interaction between these genes offers the possibility of a new drug target, which would be effective in treating Crohn"s disease - a chronic disorder causing inflammation of the gastrointestinal tract.
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Z-Cube And Yissum Research Development Company Ltd. Sign A Licensing Agreement
Z-Cube Srl, the corporate venture arm of Zambon Company SpA, and Yissum Research Development Company Ltd., the technology transfer company of the Hebrew University of Jerusalem, announced today that they have entered into a license agreement for Z-Cube to develop and commercialize an innovative nanotechnology drug delivery system for the treatment of pain. The technology was invented by Professor Elka Touitou from the Department of Pharmaceutics, Faculty of Medicine, at the Hebrew University of Jerusalem.
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Newly Released Nixon Tapes Reveal Reaction To Roe V. Wade
President Richard Nixon, who was in office when the Supreme Court issued its 1973 decision in Roe v. Wade, in secret recordings from January and February of that year discussed his views on abortion with an aide, the New York Times reports. The comments were among more than 150 hours of tape and 30,000 pages of documents made public Tuesday by the National Archives" Nixon Presidential Library. The tapes were recorded by secret microphones in the White House"s Oval Office. Nixon in the tapes expressed ambivalence over the decision, as well as concern that increased access to abortion leads to "permissiveness" and that "it breaks the family." Nixon also said that he believed there was a need for abortion in some cases, including interracial pregnancies and rape. He said, "There are times when an abortion is necessary. I know that." He added, "When you have a black and a white. Or a rape" (Savage, New York Times, 6/24).Broadcast CoverageNPR"s "All Things Considered" on Tuesday reported on Nixon"s abortion comments and political reaction to Roe at the time of the decision (Totenberg, "All Things Considered," NPR, 6/23).
Mental Health

British Medical Association Scotland Calls For An End To The Ridiculous Pricing Of Alcohol

Doctors leaders called for an end to the ridiculous pricing of alcohol for off sales in light of findings from the Scottish Schools Adolescent Lifestyle and Substance Use Survey (SALSUS). The survey shows that 52% of 13 year olds and 82% of 15 year olds have had at least one alcoholic drink and that shops and off-licences were the second most common for purchasing alcohol. Dr Peter Terry, Chairman of BMA Scotland said: "When alcohol is cheaper than bottled water, we have to worry about what message we are sending our children. "Alcohol costs our economy around ÷£1 billion every year, but the human cost is much higher. One death every six hours in Scotland is caused by alcohol. "There is no single solution to Scotland"s alcohol problem, but evidence shows that there is a direct relationship between the price of alcohol and the amount consumed. BMA Scotland supports the introduction of minimum pricing to stop retailers from selling alcohol at very low prices." British Medical Association


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