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New Alliance For Discovery Of WNT Pathway Inhibitors To Be Used In Cancer Therapy
Cancer Research Technology (CRT), Merck Serono, a division of Merck KGaA, Darmstadt, Germany, Cancer Research UK, Cardiff University and The Institute of Cancer Research (ICR) are set to begin a major new research collaboration for the first time. This will provide substantial investment in research on the WNT signalling pathway in the hope of finding new drug targets.
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Tension In Axons Is Essential For Synaptic Signaling, Researchers Report
Every time a neuron sends a signal - to move a muscle or form a memory, for example - tiny membrane-bound compartments, called vesicles, dump neurotransmitters into the synapse between the cells. Researchers report that this process, which is fundamental to the workings of the nervous system, relies on a simple mechanical reality: Tension in the axon of the presynaptic neuron is required.
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Artificial Liver For Drug Tests
If you have hay fever, headaches or a cold, it"s only a short way to the nearest chemist. The drugs, on the other hand, can take eight to ten years to develop. Until now animal experiments have been an essential step, yet they continue to raise ethical issues. "Our artificial organ systems are aimed at offering an alternative to animal experiments," says Professor Heike Mertsching of the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart. "Particularly as humans and animals have different metabolisms. 30 per cent of all side effects come to light in clinical trials." The test system, which Professor Mertsching has developed jointly with Dr. Johanna Schanz, should in future give pharmaceutical companies greater security and shorten the path to new drugs. Both researchers received the "Human-centered Technology" prize for their work.
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California Budget Could Force Seniors To Nursing Homes, Drive Up Costs

NPR reports that California"s $26.3 billion budget deficit is marginalizing seniors who rely on California state-provided health care and service to help them manage their lives. "One endangered program is in-home support services for more than 400,000 elderly and disabled. Gov. Arnold Schwarzenegger has proposed cutting those services for all but the most severe cases, which could force many who are now independent to move into nursing homes. ò€¦ Flora Mae King of San Bernadino turned 102 last Sunday. She lives alone in a senior apartment complex, relying on state-funded, in-home support for shopping and help around the house. Now, as California nears a decision on budget cuts to clear up a multi-billion dollar deficit, her in-home support will be cut and she will have to move into a nursing home" (Diamante, 7/19). The cuts could also bring higher costs to the system as the elimination of home and adult day care could push recipients into more expensive programs, The Los Angeles Times reports. "The governor"s plan to take away such care is meant to save money. But it could end up costing California more by forcing the 85-year-old (Irene Steinlage), who has Parkinson"s, osteoporosis and other ailments -- and thousands like her -- into nursing homes. ò€¦ Administration officials say tax hikes would further damage the economy, push revenue down and drive businesses and entrepreneurs out of the state, in addition to forcing California to reduce services even further." Schwarzenegger says California can no longer afford to provide services that are far more generous than other states offer, The Los Angeles Times reports (Rothfeld and Halper, 7/19). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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