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Fathers Respond To Teens' Risky Sexual Behavior With Increased Supervision
Two-thirds of American teenagers have sex by the time they"re 18. A new longitudinal study finds that when adolescents engage in risky sexual activity, fathers respond by increasing their efforts to supervise and monitor their children.
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New Detector Promises Earlier Detection Of Viral Infections
A Vanderbilt chemist and a biomedical engineer have teamed up to develop a respiratory virus detector that is sensitive enough to detect an infection at an early stage, takes only a few minutes to return a result and is simple enough to be performed in a pediatrician"s office.
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Health Care Costs Could Be Cut By Routine Diabetes Screenings
Screening adults for diabetes could result in significant cost-savings for health care systems compared to the costs of not screening individuals at all.
Cardiovascular

Enzyme Modification Brings 'Corrective Genes' Closer

Scientists from the Universitçİ de Montrçİal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to harmful agents such as chemotherapy, according to a new study published in The Journal of Biological Chemistry. "Our team modified and decoded an enzyme structure," says Joelle Pelletier, a professor at the Universitçİ de Montrçİal"s Department of Chemistry. "We discovered, to our surprise, that our intervention allowed the heart of the enzyme to increase its mobility. This unusual mobility caused the enzyme to resist the chemotherapy agent methotrexate - a result we never predicted and one that offers promise." The research team made its discovery as it sought ways to help correct genetic diseases. "Our goal is to improve the injection of corrective genes in people suffering from genetic diseases," say Pelletier who is also co-director of PROTEO, a Quebec-based research group on the function, structure and engineering of proteins. "This discovery will lead to promising new avenues." "We were intrigued to find the enzyme"s internal flexibility was impacted by our modifications and that this fact played such a crucial role for resistance," says Albert Berghuis, a professor at the McGill University Department of Biochemistry and Canada Research Chair in Structural Biology. "We can now harness this insight to further advance therapies for genetic diseases such as leukemia." Partners in research: This study was funded by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada. About the study: The paper, "Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance," published in The Journal of Biological Chemistry, was authored by Jordan P. Volpato, Elena Fossati Jonathan Blanchet, Lucie Poulin, Vanessa Guerrero and Joelle N. Pelletier of the Universitçİ de Montrçİal; Brahm J. Yachnin and Albert M. Berghuis of McGill University. Sophie Langlois University of Montreal


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