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California HIV/AIDS Advocates To Appear At Hearing On Proposed Budget Cuts
On Friday, HIV/AIDS advocates in California will appear at the state Legislature"s Budget Conference Committee hearing to urge lawmakers to block proposed health-related budget cuts, the Bay Area Reporter reports. According to the Reporter, Gov. Arnold Schwarzenegger"s (R) latest budget proposal includes cutting $67.8 million from state HIV programs and an additional $12.3 million from the AIDS Drug Assistance Program. Anne Donnelly of Project Inform said, "We realize we may have to take cuts to our programs. But let"s make sure they are minimized and that we continue to deliver the essential services to those people living with HIV and those also at risk." Next week HIV/AIDS advocates also plan to convene on the steps of the state Capitol to protest the proposed budget cuts (Bajko, Bay Area Reporter, 6/4).
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First Choice Of Renal Function Tests In Hepatectomy Patients
Although creatinine clearance (Ccr) has been measured clinically by a simple method as a preoperative renal function test, Ccr is not strictly equal to glomerular filtration rate (GFR). Recently, an equation for estimated GFR (eGFR) for Japanese individuals has been postulated, and eGFR has been accepted as equal to measured GFR in chronic kidney disease. However, there have been no previous studies regarding the reliability of eGFR as a preoperative renal function test.
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For Clues To Fetal Growth Restriction In Cloned Swine, Researchers Look To Imprinted Genes
Researchers at North Carolina State University have found that intrauterine growth restriction (IUGR), which results in low birth weight and long-term deleterious health effects in cloned swine, is linked to a type of gene - known as an imprinted gene - found only in placental mammals. Imprinted genes play an important role in the normal fetal development of all mammals, and this study could have future implications for the study of IUGR in humans.
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In Trastuzumab-Resistant Metastatic Breast Cancer, Small Molecule Inhibitor Shows Promise

Fox Chase Cancer Center researchers report that a combination of trastuzumab and neratinib (HKI-272) a novel small molecule inhibitor of the HER2 receptor (ErbB2) appears active in women with HER2-positive metastatic breast cancer who have progressed on previous trastuzumab based therapies. More than one-quarter of the women in a phase I/II trial had their tumors shrink on the combination therapy. "I think this is very promising. Neratinib induces clinically meaningful responses," says Ramona Swaby, M.D., a medical oncologist and attending physician at Fox Chase. Swaby will present the study results on Monday, June 1, at the annual meeting of the American Society of Clinical Oncology. Trastuzumab is standard therapy for women with HER2-positive metastatic breast cancer and the majority of women respond to the treatment. However, over time some women will develop resistance to the drug and their tumors will start to grow again. For these women, alternative therapies are needed. Both trastuzumab and neratinib inhibit the HER2 receptor expressed on the surface of HER2-positive breast cancer cells. Trastuzumab blocks the extracellular portion of the receptor, while neratinib blocks the intracellular portion. Researchers think that the combination may provide the one-two punch necessary to knock out the tumor cells. Forty-five women with trastuzumab-resistant breast cancer enrolled in the trial. In the phase I portion of the trial, women received either 160 mg or 240 mg neratinib daily plus trastuzumab 4 mg/kg IV loading dose followed by 2 mg/kg weekly. None of the patients experienced dose limiting toxicities. The most common grade 3/4 adverse events included diarrhea (13%), nausea (4%) and vomiting (4%). The researchers saw no evidence of cardiac toxicity with the combination. Of the 33 patients in the phase II portion of the trial who are evaluable for response, nine (27%) had an objective response to the combination therapy. Additionally, 47% were progression-free at 16 weeks, which was the primary endpoint of the trail, and the median progression-free survival was 19 weeks. Seven women continue on therapy at this time. (Updated results will be presented at the meeting.) "Trastuzumab has certainly made a difference in patient care, but there is still room for improvement," Swaby says. "For example because trastuzumab is an antibody it does not cross the blood-brain barrier so is not effective at treating or preventing brain metastases. It is incredibly heartbreaking to think you are out of the woods and then to have brain metastases occur. Neratinib, a small molecule drug that can cross the blood-brain barrier, potentially may treat brain metastases. More studies are needed" "The phase II data are snapshots of what this drug is capable of," Swaby says. "Phase III trials are underway, which I think is the right next step for this medicine. My patients in the study did well." The current study was supported by Wyeth, which makes neratinib. Wyeth participated in the study design and data analysis. Abstract #1004: Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: A phase I/II study. Oral Presentation, Monday, June 1, 10:45 a.m. - Level 2, West Hall D2 Frank Hoke Fox Chase Cancer Center


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