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Changing Paradigms In Hereditary Angioedema: A Focus On Timely Diagnosis And New Therapies
Hereditary angioedema (HAE) is an autosomal dominant disease affecting approximately 10,000 people in the United States. HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is important for physicians to understand the signs and symptoms of patients who present with HAE and to be familiar with the conventional and emerging therapies available to treat them.
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The 10th International Conference On Systems Biology Comes To Stanford University
Registration is underway for the 10th International Conference on Systems Biology (ICSB). The conference will be held at Stanford University from August 30th - September 4th.
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ACOG Endorses Full Equity For CNM(R) And CM(R) Reimbursement Under Medicare
The American College of Nurse-Midwives (ACNM), the nation"s oldest women"s health organization, is pleased to announce that the American College of Obstetricians and Gynecologists (ACOG) has reaffirmed its support for equitable reimbursement for certified nurse-midwives (CNMs) and certified midwives (CMs) within the Medicare program, a priority legislative initiative for ACNM members.
Cardiovascular

Predictive Role In Peptic Ulcer Played By Childhood Adversities

Helicobacter pylori, nonsteroidal anti-inflammatory drug use and smoking are the most important risk factors for peptic ulcer. Alcohol intake may also play a role in the development of gastric ulcers. Psychological stress may also have an impact on the onset and course of ulcer disease. However, very little is known as to whether childhood adversities involving financial problems, conflicts in the family, problems with alcohol, and matters of personal security are associated with peptic ulcer. A research article in the World Journal of Gastroenterology addresses this problem. Dr. Markku Sumanen and his colleagues of the Health and Social Support Study (HeSSup) investigated this subject in a nationwide sample of working-aged people in Finland. The participants were asked whether or not a doctor had told them that they have or have had a peptic ulcer. They were also asked to think about their childhood adversities in terms of the following questions: 1) "Did your parents divorce?" 2) "Did your family have long-lasting financial difficulties?" 3) "Did serious conflicts arise in your family?" 4) "Were you often afraid of some member of your family?" 5) "Was someone in the family seriously or chronically ill?" 6) "Did someone in the family have problems with alcohol?" The most common childhood adversities to emerge were long-lasting financial difficulties in the family, serious conflicts in the family and someone in the family having been seriously or chronically ill. All adversities reported were more common among peptic ulcer patients than among other respondents. Alcohol problems in the family and fear of some member of the family were also more common among peptic ulcer patients than among other respondents. With regard to parental divorce there was no statistically significant difference between the two groups. Age- and sex-adjusted odds ratios (ORs) of childhood adversities for peptic ulcer were statistically significant, indicating that participants with childhood adversities had a higher proportional risk of developing peptic ulcer. Adjusting also for smoking, heavy drinking, stress and current NSAID use had no further influence. Long-lasting financial difficulties in the family had the greatest influence. According to the findings there is reason to believe that stress factors during childhood maintain a connection with the development of peptic ulcers. Childhood adversities are not necessarily true risk factors for peptic ulcer, but may play a predictive role in the development of the disease. A more comprehensive understanding of peptic ulcer patients is worth aspiring to. Reference: Sumanen MPT, Koskenvuo MJ, Sillanmç¤ki LH, Mattila KJ. Peptic ulcer and childhood adversities experienced by working-aged people. World J Gastroenterol 2009; 15(27): 3405-3410 http://www.wjgnet.com/1007-9327/15/3405.asp Lin Tian World Journal of Gastroenterology


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