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In Trastuzumab-Resistant Metastatic Breast Cancer, Small Molecule Inhibitor Shows Promise
Fox Chase Cancer Center researchers report that a combination of trastuzumab and neratinib (HKI-272) a novel small molecule inhibitor of the HER2 receptor (ErbB2) appears active in women with HER2-positive metastatic breast cancer who have progressed on previous trastuzumab based therapies. More than one-quarter of the women in a phase I/II trial had their tumors shrink on the combination therapy.
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Dysport Proves Safe, Effective Anti-Wrinkle Treatment, Plastic Surgeons Find
The new anti-wrinkle facial filler Dysport, which could be used as an alternative to Botox, noticeably reduced frown lines between the eyes, according to users and independent reviewers in a study involving plastic surgeons at UT Southwestern Medical Center.
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OSI Pharmaceuticals Announces Acceptance Of Tarceva Supplemental New Drug Application For Review By The U.S. Food And Drug Administration
OSI Pharmaceuticals, Inc. (NASDAQ: OSIP) announced that the U.S. Food and Drug Administration (FDA) has accepted for filing and review the supplemental New Drug Application (sNDA) for the use of Tarceva® (erlotinib) as a first-line maintenance treatment for patients with advanced non-small cell lung cancer (NSCLC) who have not progressed following first-line treatment with platinum-based chemotherapy. Based upon the March 17th receipt of filing the FDA Prescription Drug Fee Act (PDUFA) review date will be on or about January 18, 2010.
Endocrinology

Proposed House Amendment Would Impact Needle Exchange Programs In Washington, D.C.

A proposed amendment to Washington, D.C."s federal appropriation for 2010 "would prohibit the city from using federal funds to distribute needles for the "injection of illegal drugs ò€¦ within 1,000 feet of a public or private day care center, elementary school, vocational school, secondary school, college, junior college, university, public swimming pool, park, playground, video arcade or youth center,"" the Washington Post reports. Local HIV/AIDS advocates "are concerned that [the] proposed amendment ò€¦ would drastically reduce public funding for needle exchange programs and take away a weapon in the fight against HIV and AIDS," according to the Post. A companion bill in the Senate does not contain language prohibiting the use of federal dollars for needle exchange programs. "Del. Eleanor Holmes Norton (D) urged her colleagues to fight the amendment which is before the full House this afternoon," the article states. The district has provided $700,000 in the past year to four non-profit organizations for needle exchange programs (Fears, 7/16). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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