Popular Articles

APhA Submits Recommendations For The Term "Meaningful Use" In TheDevelopment Of Policy Related To Electronic Health Records
The American Pharmacists Association (APhA) submitted comments to the Office of the National Coordinator for Health Information Technology"s (ONC) request for feedback on determining criteria for the term "meaningful use" of electronic records (EHRs), prepared by ONC"s HIT Policy Committee.
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Ghana Launches Public-Private Partnership To Control Malaria
Ghana"s Ministry of Health recently launched the Nationwide Mosquito Control Programme (NAMCOP) in conjunction with the waste management company Zoomlion Ghana Limited, the Ghanaian Chronicle/allAfrica.com reports (Akweetey, Ghanaian Chronicle/allAfrica.com, 6/19). George Sipa Yankey, Ghana"s health minister, said the government is committed to eliminating malaria and that the initiative will be part of a sustained effort so that Ghana can be the first country in West African to eliminate the disease. He said the government also plans to help the region by transferring local malaria elimination skills to other countries in West Africa.
News of the day
Biological 'Fountain Of Youth' Discovered In New World Bat Caves
Scientists from Texas are batty over a new discovery which could lead to the single most important medical breakthrough in human history - significantly longer lifespans. The discovery, featured on the cover of the July 2009 print issue of The FASEB Journal, shows that proper protein folding over time in long-lived bats explains why they live significantly longer than other mammals of comparable size, such as mice.
Cardiovascular

'SIRT'ain Security: The Protein SIRT3 Protects The Heart

Sirtuin proteins have been shown to promote longevity in many organisms, and increased expression of one sirtuin protein, SIRT3, has been linked to increased human lifespan. New data, generated in mice, by Mahesh Gupta and colleagues, at the University of Chicago, Chicago, has revealed that Sirt3 helps protect the mouse heart. In the study, the heart of mice lacking Sirt3 was found to show signs of becoming enlarged (a process known as cardiac hypertrophy), at about 8 weeks of age. Further, these mice responded dramatically to conditions that induce cardiac hypertrophy, whereas mice overexpressing Sirt3 were protected from cardiac hypertrophy under the same conditions. Additional analysis revealed the mechanism by which Sirt3 blocks the cardiac hypertrophic response, thereby providing protection to the mouse heart. Specifically, it acts in heart muscle cells via the protein Foxo3a to increase expression of anti-oxidant proteins, thereby reducing levels of damaging oxidants. TITLE: Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice AUTHOR: Mahesh P. Gupta University of Chicago, Chicago, Illinois, USA. PDF of this article Karen Honey Journal of Clinical Investigation


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