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Alzheimer's Disease: Disclosing Genetic Risk Does Not Cause Psychological Distress
Researchers from Boston University School of Medicine (BUSM) have shown that disclosing genetic risk information to adult children of patients with Alzheimer"s disease (AD) who request this information does not result in significant short-term psychological distress. The report from the REVEAL Study*, which appears in the July 16 issue of the New England Journal of Medicine, is the first randomized trial to disclose to participants whether or not they carried the íµ4 variant of the APOE gene, a variant that has been found to increase the risk of developing AD. The study demonstrated that test-related distress was reduced among those who learned that they were APOE íµ4 negative, and was only transiently increased among those who learned they were APOE íµ4 positive. The study also showed that persons with high levels of emotional distress before undergoing genetic testing were more likely to have emotional difficulties after disclosure.
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Risk Factors Of Cardiovascular Disease Rising In Poor, Young
Cardiovascular disease is increasing in adults under 50 and those of lower socioeconomic status, despite recent trends which show that cardiovascular disease is declining in Canada overall, say researchers at the Peter Munk Cardiac Centre. Untreated cardiovascular disease can lead to heart failure, coronary artery disease and death, and is the most common cause of hospitalization in North America.
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Nexavar® In Combination With Chemotherapy Shown To Extend Progression-Free Survival In Patients With Advanced Breast Cancer
Bayer HealthCare AG and Onyx Pharmaceuticals, Inc. announced that their first cooperative group-sponsored randomized Phase II trial in advanced metastatic breast cancer met its primary endpoint of progression-free survival. The study evaluated Nexavar® (sorafenib) tablets in combination with the oral chemotherapeutic, capecitabine, in patients with locally advanced or metastatic HER-2 negative breast cancer. Study findings demonstrated that the median progression-free survival was extended in patients treated with Nexavar and capecitabine compared to patients receiving capecitabine and placebo. These results were statistically significant (p-value = 0.0006). In this trial, the safety and tolerability of the combination was as expected and did not show any new or unexpected toxicities. A complete data analysis from this study is expected to be presented at an upcoming scientific meeting.
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Sound Imaging: Clever Acoustics Help Blind People See The World

Video from portable cameras is analysed to calculate the distance of obstacles and predict the movements of people and cars. This information is then transformed and relayed to a blind person as a three-dimensional "picture" of sound. The concept is apparently simple and two prototypes have been successfully tested. Laser and digital video cameras become the eyes for the blind man and see the objects and activity going on around him. Researchers from the University of Bristol have developed powerful real-time image processing and some clever algorithms to then identify objects and obstacles, such as trees, street furniture, vehicles and people. The system uses the stereo images to create a "depth map" for calculating distances. The system can also analyse moving objects and predict where they are going. So much for the image processing, but how do you present this visual information to a blind person? Technology developed at the University of Laguna in Spain makes it possible to transform spatial information into three-dimensional acoustic maps. A blind person wears headphones and hears how sounds change as they move around. The stereo audio system makes it possible to place sounds so that the brain can interpret them as a point in space. Sounds get louder as you walk towards objects, quieter as you move away. Objects to your right are heard on your right, and if you move your head the sound moves too. And if something is heading right for you, you"ll hear it coming, with a tone that tells you to get out of the way. The full picture The EU-funded CASBLiP project was conceived to integrate the image processing and acoustic mapping technologies into a single, portable device that could be worn by blind people and help them to navigate outdoors. The University of Laguna worked to adapt its acoustic mapping system and the University of Bristol refined its image processing algorithms. The device also incorporates a gyroscopic sensor developed by the University of Marche, Italy. This component, called the head-positioning sensor, detects how the wearer moves his head. It feeds back the position of the head and the direction it is facing, so that the relative position of the sounds being played to the wearer also move as expected. For example, if you turn your head towards a sound on the right, the sound must move left towards the centre of the sound picture. Vision for the future After three years, the consortium has produced two prototype devices mounted on a helmet. They have been tested successfully in trials by blind people in several real-world environments, including busy streets. Two blind institutions (the German Federation of the Blind and Partially Sighted and the Francesco Cavazza Institute, Italy) were heavily involved in the testing programme. The first design (M1) uses a laser sensor developed by Siemens and originally intended to detect passengers in cars. It can calculate the distance to objects within 0 to 5m in a 60Âô field of view. The system is mounted inside glasses and cannot be seen by others because it uses infrared light. The M1 has been extensively tested by blind users who are able to recognise items, such as chairs and trees, from the sound picture they receive. A second version (M2) adds two digital video cameras to either side of a helmet. It can detect moving objects and predict their path. The University of Marche has also worked closely with the Cavazza Institute to build a complementary GPS location system. This technology could be used to pinpoint the location of a blind person and integrate the device with additional data s, such as mapping services. It could provide the wearer with verbal directions to their destination. "We know that the technology works," says Guillermo Peris-Fajarnés, who coordinated the project from the Research Group on Graphic Technologies at the Universidad Politecnica de Valencia. "Our tests have been very successful and blind people have been able to navigate comfortably in controlled tests and even along a normal street." "There is still a lot of development work to do before this could go on the market, especially to prove that the system is 100% reliable," Peris-Fajarnés notes. "You can"t risk it going wrong while a user is crossing the road." He says the consortium has decided to continue work on this aspect beyond the end of the EU funding period. Nevertheless, Peris-Fajarnés is confident that the device could be commercialised: "We are now looking for manufacturing partners to explore the possibilities for a commercially viable product. There"s no other system like this available and it should complement existing aids, such as the white stick. But its commercial success will depend on miniaturising the system and mounting the cameras onto glasses." "In my personal opinion, anything that can offer some more autonomy to the blind person is positive," said one tester. CASBLiP received funding from the ICT strand of the EU"s Sixth Framework Programme for research. ICT Results


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